STAT3 Inhibitor XI, STX-0119

STAT3 Inhibitor XI, STX-0119
N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100 µM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
产品信息
Form  Greyish to off-white solid
Molar mass  382.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥90% by HPLC
Solubility  DMSO
Chemical formula  C22H14N4O3
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling