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Aromatase Inhibitor II, Letrozole Product information
Form White powder
Molar mass 285.3
Protect from Light Yes
Packaged under inert gas Yes
Purity ≥99% by HPLC
Solubility DMSO
Chemical formula C17H11N5
CAS number 112809-51-5
An orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors |