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3-Nitropropionic acid
3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
产品信息
Form Light yellow powder
Molar mass 119.1
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by NMR
Solubility DMSO or EtOH
Chemical formula C3H5NO4
CAS number 504-88-1
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxic
安全标示
S Phrase S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 25-36/37/38
Toxic if swallowed.
Irritating to eyes, respiratory system and skin. |