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PDE4D Inhibitor, GEBR-7b
GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
产品信息
Form Pale yellow semi-solid
Molar mass 390.47
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H30N2O5
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling |