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NF-κB SN50, Cell-Permeable Inhibitor Peptide
AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
产品信息
Peptide Sequence H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Form Lyophilized
Formulation Supplied as a trifluoroacetate salt.
Primary Target translocation of the NF-κB active complex into the nucleus
Molar mass 2781.5
Hygrocopic 是的
Cell permeable 是的
Purity ≥97% by HPLC
Sold on the basis of peptide content 是的
Solubility H2O
Chemical formula C129H230N36O29S
Declaration Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |