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HMTase Inhibitor V, UNC0224
A quinazolinamine compound that inhibits G9a and GLP histone H3K9 methyltransferase activity (IC50 ~50 and 54 nM, respectively) by targeting the lysine binding channel, while affecting muscarinic M2 receptor and histamine H1 receptor only at much higher concentrations (by 82% and 31%, respectively, at 1 µM) and exhibiting little activity against SET7/9, SET8/PreSET7, PRMT3, JMJD2E (IC50 >40 µM), or a panel of 30 GPCR, ion channels, and transporters (<20% inhibition at 1 µM).
产品信息
Form Liquid
Molar mass 503.7
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C26H43N7O2 • H2O
CAS number 1197196-48-7
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |