Hdm2 E3 Ligase Inhibitor II, HLI373 A cell-permeable pyrimidoquinoline-dione compound that upregulates cellular p53 and E3 ubiquitin ligase HDM2/MDM2 protein levels (optimal conc. = 5 µM in RPE cells) by directly inhibiting MDM2 E3 ubiquitin ligase activity. Shown to induce apoptotic cell death in E1A-transformed, but not non-transformed, RPE cells and be more active toward wild-type p53-expressing than mutant p53-expressing cancer cells (≥67% vs. ≤37% death induction, respectively; 25 µM 30 h treatment). 产品信息 Form Cream solid Molar mass 414.3 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥98% by HPLC Solubility H2O Chemical formula C18H23N5O2 • 2HCl CAS number 502137-98-6 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Regulatory Review
