Cdk4 Inhibitor V 4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione A cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in rat liver microsomes stability assays) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting Cdk4/D1 inhibitor (IC50 = 30 nM) and an effective antiproliferative agent against HCT116 and MCF-7 cancer cells (IC50 = 0.73 and 0.88 µM, respectively), affecting Cdk2/E and Cdk1/B only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively). 产品信息 Form Caramel powder Molar mass 479.3 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥98% by HPLC Solubility DMSO Chemical formula C19H18IN3O4 CAS number 943746-57-4 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Regulatory Review
