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GSK-3 Inhibitor IX
A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
其他选项
361556 GSK-3 Inhibitor IX, Control, MeBIO
361552 InSolution™ GSK-3 Inhibitor IX
产品信息
Form Purple solid
Primary Target GSK-3α/β
Primary Target IC50 5 nM
Secondary target IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively
Molar mass 356.2
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C16H10BrN3O2
CAS number 667463-62-9
商店和运输信息
Storage +2°C to +8°C
Ship Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |