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Cyclopamine-KAAD
3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II
A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807).
产品信息
Form Pale yellow solid
Primary Target Hh signaling in Shh-light2 assay
Primary Target IC50 20 nM
Secondary target in P2Ptch-/-cells (IC50 = 50 nM)
Molar mass 698.0
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥70% by HPLC (sum of two isomers)
Solubility DMSO, EtOH, or MeOH
Chemical formula C44H63N3O4
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Harmful
安全标示
S Phrase S: 22-36/37
Do not breathe dust.
Wear suitable protective clothing and gloves.
R Phrase R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed. |