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InSolution™ AMPK Inhibitor, Compound C•2HCl
AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
产品信息
Form Liquid
Formulation A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H2O.
Molar mass 399.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C24H25N5O
CAS number 866405-64-3
商店和运输信息
Storage -20°C
Ship Dry Ice Only |