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1400W dihydrochloride
A highly selective iNOS inhibitor
Product Overview
Product Name: 1400W dihydrochloride
Alternate Name/Synonyms: N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl
Description: Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Kᵢ values of 2 and 50 µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 214358-33-5
Molecular Formula: C₁₀H₁₅N₃ . 2HCl
Molecular Weight: 250.17
Purity: ≥98% by NMR
Solubility:Water (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(=NCC1=CC(=CC=C1)CN)N.Cl.Cl
InChi: InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChi Key: WDJHSQZCZGPGAA-UHFFFAOYSA-N
PubChem CID: 2733515
MDL Number: MFCD03428622
USAGE: For Research Use Only! Not For Use in Humans. |