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TAME Hydrochloride
An anaphase-promoting complex/cyclosome (APC/C) inhibitor
Product Overview
Product Name: TAME Hydrochloride
Alternate Name/Synonyms: N-p-Tosyl-L-arginine methyl ester hydrochloride
Description: A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 1784-03-8
Molecular Formula: C₁₄H₂₂N₄O₄S.HCl
Molecular Weight: 378.87
Purity: ≥98% by TLC
Solubility:Water (50 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl
InChi: InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
InChi Key: JIQFFACVQXXHMY-UHFFFAOYSA-N
PubChem CID: 3083734
MDL Number: MFCD00012578
USAGE: For Research Use Only! Not For Use in Humans. |