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Motesanib
A potent multikinase inhibitor selective to VEGFRs and PDGFrs
Product Overview
Product Name: Motesanib
Alternate Name/Synonyms: AMG-706
Description: Cell-permeable. Motesanib, also known as AMG-706, is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC₅₀ values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). It also potently inhibits angiogenesis and induces regression in tumor xenografts.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 453562-69-1
Molecular Formula: C₂₂H₂₃N₅O
Molecular Weight: 373.45
Purity: ≥98% by HPLC
Solubility: DMSO (200 mg/ml) or EtOH (40 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
InChi: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
InChi Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N
PubChem CID: 11667893
MDL Number: MFCD10567689
USAGE: For Research Use Only! Not For Use in Humans. |