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ZM 447439
A potent Aurora B kinase inhibitor
Product Overview
Product Name: ZM 447439
Alternate Name/Synonyms: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Description: Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 μM).
Peptide Sequence: N/A
Appearance: Orange solid
Formulation: N/A
CAS Number: 331771-20-1
Molecular Formula: C₂₉H₃₁N₅O₄
Molecular Weight: 513.59
Purity: ≥98% by HPLC
Solubility:DMSO (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
nChi: InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChi Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N
PubChem CID: 9914412
MDL Number: MFCD08703125
USAGE: For Research Use Only! Not For Use in Humans. |