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NSC 66811
Potent MDM2 inhibitor
Product Overview
Product Name: NSC 66811
Alternate Name/Synonyms: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Description: Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 6964-62-1
Molecular Formula: C₂₃H₂₀N₂O
Molecular Weight: 340.42
Purity: ≥97% by HPLC
Solubility:DMSO (~ 100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChi Key: WEENRMPCSWFMTE-UHFFFAOYSA-N
PubChem CID: 248986
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |