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Masitinib
A potent c-KIT, PDGF and FGFR nhibitor
Product Overview
Product Name: Masitinib
Alternate Name/Synonyms: AB-1010
Description: Cell-permeable. A protein tyrosine kinase (PTK) inhibitor. targeting KIT that is active, orally bioavailable in vivo, and has low toxicity. Masitinib also potently inhibited recombinant PDGFR and the intracellular kinase Lyn, and to a lesser extent, fibroblast growth factor receptor 3. In contrast, masitinib demonstrated weak inhibition of ABL and c-Fms and was inactive against a variety of other tyrosine and serine/threonine kinases.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 790299-79-5
Molecular Formula: C₂₈H₃₀N₆OS
Molecular Weight: 498.64
Purity: ≥99% by HPLC
Solubility:DMSO (>100 mg/ml) or EtOH (4 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
InChi: InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)
InChi Key: WJEOLQLKVOPQFV-UHFFFAOYSA-N
PubChem CID: 10074640
MDL Number: MFCD09954132
USAGE: For Research Use Only! Not For Use in Humans. |