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LDN193189
A potent BMP type I receptor inhibitor
Product Overview
Product Name: LDN193189
Alternate Name/Synonyms: 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, hydrochloride; DM-3189
Description: Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189 has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1062368-24-4 (free base)
Molecular Formula: C₂₅H₂₂N₆.HCl
Molecular Weight: 442.94
Purity: ≥97% by HPLC
Solubility:DMSO (10 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
InChi: InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChi Key: CDOVNWNANFFLFJ-UHFFFAOYSA-N
PubChem CID: 25195294
MDL Number: MFCD17169988
USAGE: For Research Use Only! Not For Use in Humans. |