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Gemcitabine Hydrochloride
An anticancer agent
Product Overview
Product Name: Gemcitabine Hydrochloride
Alternate Name/Synonyms: 2′,2′-difluoro-2′-deoxycytidine; Gamcitabine; Gemcitera; Gemsar; Gemzar; LY-188011
Description: A nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 122111-03-9
Molecular Formula: C₉H₁₁F₂N₃O₄•HCl
Molecular Weight: 299.66
Purity: ≥98% by HPLC
Solubility:DMSO (10 mg/ml) or H₂O (25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl
InChi: InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChi Key: OKKDEIYWILRZIA-OSZBKLCCSA-N
PubChem CID: 60749
MDL Number: MFCD01735988
USAGE: For Research Use Only! Not For Use in Humans. |