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PIK-90
Cayman Chemical Item Number 10010749
Description PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively).1↗ Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells.1↗ It also blocks proliferation of glioma cells in vitro.2↗ By inhibiting P110α, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.3↗
Synonyms PIK-85
Formal Name N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
CAS Number 677338-12-4
Molecular Formula C18H17N5O3
Formula Weight 351.4
Formulation A crystalline solid
Purity ≥98%
λmax 229, 276 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COC1=CC=C2C(N=C(NC(C3=CN=CC=C3)=O)N4C2=NCC4)=C1OC
InCHI Code 1S/C18H17N5O3/c1-25-13-6-5-12-14(15(13)26-2)21-18(23-9-8-20-16(12)23)22-17(24)11-4-3-7-19-10-11/h3-7,10H,8-9H2,1-2H3,(H,21,22,24)
InCHI Key ZJAVHOMVDCMAMF-UHFFFAOYSA-N |