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Capecitabine-d8
Cayman Chemical Item Number 10010685
Description Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-flyorouracil.
Formal Name 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl)]-cytidine-d8
Molecular Formula C15H22D8FN3O6
Formula Weight 367.4
Formulation A crystalline solid
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OC(NC(C(F)=CN1[C@@H]2O[C@H](C)[C@@H](O)[C@H]2O)=NC1=O)=O
InCHI Code 1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1/i3D2,4D2,5D2,6D2
InCHI Key GAGWJHPBXLXJQN-WSMAYNAZSA-N |