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SB 202190
Cayman Chemical Item Number 10010399
Description SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively.1↗,2↗ When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs).2↗ Pyridinyl imidazole inhibitors, including this compound, directly bind p38 MAP kinases in the ATP binding pocket.3↗ Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.4↗,5↗,6↗
Formal Name 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol
CAS Number 152121-30-7
Molecular Formula C20H14FN3O
Formula Weight 331.3
Formulation A crystalline solid
Purity ≥98%
λmax 202, 295 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES FC(C=C1)=CC=C1C(N=C(C2=CC=C(O)C=C2)N3)=C3C4=CC=NC=C4
InCHI Code 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InCHI Key QHKYPYXTTXKZST-UHFFFAOYSA-N |