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SAHA
Cayman Chemical Item Number 10009929
Description SAHA is an histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I and class II HDACs at around 50 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.1↗ SAHA is currently in advanced clinical trials for the treatment of cancer.
Synonyms Zolinza™
Suberoylanilide Hydroxamic Acid
Vorinostat
Formal Name N1-hydroxy-N8-phenyl-octanediamide
CAS Number 149647-78-9
Molecular Formula C14H20N2O3
Formula Weight 264.3
Formulation A crystalline solid
Purity ≥98%
λmax 243 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
InCHI Code 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InCHI Key WAEXFXRVDQXREF-UHFFFAOYSA-N |