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PRE-084 (hydrochloride)
Cayman Chemical Item Number 9001329
(CAS 75136-54-8)
Description
Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin.1↗ PRE-084 is a high affinity, sigma receptor agonist, selective for the σ1 subtype (Kis = 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively).2↗ It is a potent ligand of the σ receptor (IC50 = 44 nM) without appreciable affinity for PCP receptors (IC50 > 100,000 nM).2↗ PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.3↗,4↗,5↗,6↗
Formal Name 1-phenyl-2-(4-morpholinyl)ethyl ester-cyclohexanecarboxylic acid, monohydrochloride
CAS Number 75136-54-8
Molecular Formula C19H27NO3 • HCl
Formula Weight 353.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3.Cl
InCHI Code 1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InCHI Key QUJWFJNHTBKCLU-UHFFFAOYSA-N |