QS11 Bulk Request Synergizers with Wnt3a to activate the Wnt/β-catenin pathway. Binds and inhibits GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), thus activating ARF. It has also been suggested that a possible mechanism by which QS11 synergizes Wnt is through ARFGAP1 inhibition leading to increased β-catenin translocation via ARF activation. Product Specification Alternative Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-ylmethyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol Formula: C35H33N5O2 MW: 567.7 CAS: 944328-88-5 Purity: ≥98% (TLC) Appearance: White solid. Solubility: Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml). Long Term Storage: -20°C Use/Stability: Stable for at least 6 months after receipt when stored at -20°C.
