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Glipizide
Description
An oral hypoglycemic agent that enhances insulin secretion by inhibiting its metabolic clearance. It blocks ATP-dependent K+ channels in pancreatic b cells and brain GABA containing neurons resulting in insulin release.
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Specifications
Cas No. 29094-61-9
Product ID G4634
Product Name Glipizide
Chemical Name N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl-5-methylpyrazinecarboxamide
Synonym Glibenese; Blucotrol; Minidiab; Ozidia
Formula Wt. 445.54
Melting Point 208
Purity ≥98%
Solubility Soluble in DMSO (48mg/mL) or methanol (1.9mg/mL)..
Store Temp Ambient
References Brogden RN, Heel RC, Pakes GE et al. Drugs. 18:329-53 (1979). Barzilai N, Groop PH, Groop, DeFronzo RA. Acta Diabetol. 32:273-8 (1995). Lamensdorf I, He L, Nechushtan A et al. Eur J Pharmacol. 388:147-54 (2000).
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