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Glimepiride
Description
A sulfonylurea hypoglycemic agent acts with the lowest ratio of insulin release to glucose release when compared with other sulfonylureas. It increases cardiac glucose uptake by enhancing protein expression of glucose transports -1 and -4 independent of insulin responsiveness.
Specifications
Cas No. 93479-97-1
Product ID G4535
Product Name Glimepiride
Chemical Name 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
Synonym HOE-490; Amarel
Formula Wt. 490.62
Melting Point 212
Purity ≥98%
Solubility Soluble in DMSO (25mg/mL).
Store Temp 4oC
References Schiekofer S, Rudofsky G Jr, Andrassy M et al. Diabetes Obes Metab. 5:251-61 (2003). Bahr M, von Holtey M, Muller G, Eckel. J. Endocrinology. 136:2547-53 (1995).
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