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Doramapimod
Description
A pyrazole phenyl urea derivative is a reversible, competitive inhibitor of p38 MAP kinase. It interferes with ATP binding of p38. It also blocks tumor necrosis factor-alpha and IL-1β synthesis.
Specifications
Cas No. 2859873-48-4
Product ID D5868
Product Name Doramapimod
Chemical Name 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
Synonym 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
Formula Wt. 527.66
References Pargellis, C., Tong, L., Churchill, L., et al. Nat. Struct. Biol. 9, 268-272 (2002).
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