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Docetaxel
Description
A derivative of paclitaxel. Microtubule inhibitor. Induces apoptosis and inhibits angiogensis.
Specifications
Cas No. 114977-28-5
Product ID D5709
Product Name Docetaxel
Chemical Name (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,- 11S,12S,12aR,12bS)-12b-(acetyloxy)-12(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11- trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonym N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; Taxotere
Formula Wt. 807.89
Melting Point 186oC-190oC
Purity ≥98%
Solubility Soluble in DMSO. Insoluble in water.
Store Temp -20oC
References Wang, T.H., Wang, N.R., Mason, K.A., Milas, L. Mund-, Kiefer- und Gesichtschirurgie. 3:210-2 (1999). Matsuura, M., Hasegawa, M., Hayakawa, K., et al. Oncol. Reports. 7:289-93 (2000). |