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Dihydrokainic acid
Description
The saturated analog of kainic acid. Reduction of the isopropylene side-chain destroys the affinity to binding sites. It enhances the antitumor activity of doxorubicin presumably acting as a glutamate transporter inhibitor.
Specifications
Cas No. 52497-36-6
Product ID D3328
Product Name Dihydrokainic acid
Synonym 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
Formula Wt. 215.25
Melting Point 285oC(dec.)
Purity ≥98%
Solubility Soluble in water (>110mg/mL).
Store Temp Ambient
References London, ED.; Klemm, N.; Coyle, JT. Brain Res. 192:463-476 (1980). Sadzuka, Y.; Yamashita, Y.; Sugiyama, T.; Sonobe, T. Cancer Letters 179:157-163 (2002).
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