The Silencer® Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry. A choice of Silencer® Select siRNAs are available—Pre-Designed or Validated. Silencer® Select Pre-Designed siRNAs are guaranteed-to-silence based on their proven design while the Silencer® Select Validated siRNAs are functionally tested to reduce target gene expression. Sets of Silencer® Select siRNA Libraries are also available in tubes or plate for high throughput screening. The Silencer® Select Positive and Negative Control RNAs should be included in every siRNA experiment. The benefits of using Silencer® Select siRNAs include: •Potent—up to 100-fold more potent than currently available siRNAs and fewer off-target effects •Most Specific—LNA® chemical modifications reduce off-target effects by up to 90% •Reliable—demonstrated improvements in consistency and reliability of phenotypic results •Guaranteed—100% guaranteed to silence, the best guarantee in the industry
