(-)-Neplanocin A

产品编号：	10584-5 查看说明书
产品名称：	(-)-Neplanocin A .0 订购此产品
供应商：	Cayman
规格：	5 mg
目录价：	26611.2
库存状态：	3周
CAS编号：	72877-50-0
应用范围：
种属来源：
相关信息：
(−)-Neplanocin A Exclusive Cayman Chemical Item Number 10584 Description S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM).1↗ It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity.2↗,3↗,4↗,1↗ Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).3↗,5↗ Formal Name 5R-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol CAS Number 72877-50-0 Molecular Formula C11H13N5O3 Formula Weight 263.3 Formulation A crystalline solid Purity ≥98% λmax 262 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES OCC1=C[C@@H](N2C=NC3=C2N=CN=C3N)[C@H](O)[C@@H]1O InCHI Code 1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 InCHI Key XUGWUUDOWNZAGW-VDAHYXPESA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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