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AM1172
Cayman Chemical Item Number 10005223
Description
Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity.1↗ This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.2↗ AM1172 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis.3↗ Structurally, AM1172 is the “reversed” isomer of AM404, constructed using arachidonyl amine; this may account for its metabolic stability. In mouse cortical neurons, AM1172 blocked the uptake of tritiated AEA with an EC50 of about 1.5 µM.3↗
Formal Name N-5Z,8Z,11Z,14Z-eicosatetraenyl-4-hydroxy-benzamide
CAS Number 251908-92-6
Molecular Formula C27H39NO2
Formula Weight 409.6
Formulation A solution in ethanol
Purity >98%
λmax 209, 253 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCNC(=O)c1ccc(O)cc1
InCHI Code 1S/C27H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-28-27(30)25-20-22-26(29)23-21-25/h6-7,9-10,12-13,15-16,20-23,29H,2-5,8,11,14,17-19,24H2,1H3,(H,28,30)/b7-6-,10-9-,13-12-,16-15-
InCHI Key XCWBOAHOJHPWLA-DOFZRALJSA-N |