CCG-100602

产品编号：	10787-10 查看说明书
产品名称：	CCG-100602 .0 订购此产品
供应商：	Cayman
规格：	10 mg
目录价：	877.8
库存状态：	3周
CAS编号：	1207113-88-9
应用范围：
种属来源：
相关信息：
CCG-100602 Cayman Chemical Item Number 10787 Description The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding.1↗ CCG-100602 is a CCG-1423 analog developed for improved selectivity, potency, and attenuated cytotoxicity relative to its parent compound. CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM. At 100 μM, CCG-100602 demonstrates 72% inhibition of PC3 cell invasion into a Matrigel model of metastasis, exhibiting an efficacy:toxicity profile superior to that of CCG-1423 at 10 μM.2↗ Formal Name 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)-3-piperidinecarboxamide CAS Number 1207113-88-9 Molecular Formula C21H17ClF6N2O2 Formula Weight 478.8 Formulation A crystalline solid Purity ≥98% λmax 250 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES ClC(C=C1)=CC=C1NC(C(C2)CCCN2C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)=O InCHI Code 1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)29-18(31)12-2-1-7-30(11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12H,1-2,7,11H2,(H,29,31) InCHI Key MOQCFMZWVKQBAP-UHFFFAOYSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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