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CD36 Monoclonal Antibody (Clone JC63.1) (azide free)Exclusive
Cayman Chemical Item Number 10009893
Description
Antigen:recombinant adenovirus expressing full-length mouse CD36 · Clone designation:JC63.1 · Host:CD36 null mouse · Application(s):FC, functional blocking, and ICC · CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions.1↗,2↗,3↗,4↗ This membrane glycoprotein can internalize fatty acids which activate PPARγ and stimulate further expression of CD36.5↗,6↗ This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments and post-apoptotic monocytes and neutrophils.7↗,8↗,9↗,10↗ CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia.11↗ Positive controls include adipose and heart tissue, platelets, and macrophages.
Synonyms GPIIIb Hexarelin Receptor Thrombospondin Receptor oxLDL GPIV
Formulation 100 µg IgA in 500 µl PBS, pH 7.2
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity Human CD36 Mouse CD36 Rat CD36 |