Cl-Amidine

产品编号：	10599-10 查看说明书
产品名称：	Cl-Amidine .0 订购此产品
供应商：	Cayman
规格：	10 mg
目录价：	7315
库存状态：	3周
CAS编号：	913723-61-2
应用范围：
种属来源：
相关信息：
Cl-Amidine Cayman Chemical Item Number 10599 Description Protein arginine deiminase 4 (PAD4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which plays a large role in regulating gene expression.1↗ Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis.{18134;18137} Cl-amidine is an inhibitor of PAD4 deimination activity with an IC50 value of 5.9 μM in an in vitro activity assay.2↗ It irreversibly inactivates (kinact/KI = 13,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity.2↗ Cl-amidine also inhibits PAD1 and PAD3 with IC50 values of 0.8 and 6.2 μM, respectively.3↗ Cl-amidine is cytotoxic to HL-60, MCF7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05 and 1 μM, respectively).4↗ In a CIA mouse model of inflammatory arthritis, Cl-amidine dose dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.5↗ Formal Name N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide CAS Number 913723-61-2 Molecular Formula C14H19ClN4O2 • CF3CO2H Formula Weight 424.8 Formulation A crystalline solid Purity ≥95% Stability 1 year Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES O=C(N[C@@H](CCCNC(CCl)=N)C(N)=O)C1=CC=CC=C1.FC(F)(C(O)=O)F InCHI Code 1S/C14H19ClN4O2.C2HF3O2/c15-9-12(16)18-8-4-7-11(13(17)20)19-14(21)10-5-2-1-3-6-10;3-2(4,5)1(6)7/h1-3,5-6,11H,4,7-9H2,(H2,16,18)(H2,17,20)(H,19,21);(H,6,7)/t11-;/m0./s1 InCHI Key WUSNMVYWOLUWDD-MERQFXBCSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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