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CMPF
Cayman Chemical Item Number 10007133
Description Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.1↗ CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).2↗,3↗ CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.3↗ Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.3↗
Formal Name 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid
CAS Number 86879-39-2
Molecular Formula C12H16O5
Formula Weight 240.3
Formulation A crystalline solid
Purity ≥98%
λmax 260 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCc1oc(CCC(=O)O)c(C(=O)O)c1C
InCHI Code 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
InCHI Key WMCQWXZMVIETAO-UHFFFAOYSA-N |