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Combrestatin A4
Cayman Chemical Item Number 10007412
Description Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. CA4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively.1↗ CA4 inhibits tubulin polymerization with an IC50 value of 2.2 µM.2↗
Synonyms CA4
CRC 87-09
Combretastatin A4
Formal Name 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol
CAS Number 117048-59-6
Molecular Formula C18H20O5
Formula Weight 316.4
Formulation A crystalline solid
Purity ≥98%
λmax 222, 296 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1OC
InCHI Code 1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InCHI Key HVXBOLULGPECHP-WAYWQWQTSA-N |