coumarin-SAHA

产品编号：	10671-1 查看说明书
产品名称：	coumarin-SAHA .0 订购此产品
供应商：	Cayman
规格：	1 mg
目录价：	431.2
库存状态：	3周
CAS编号：	1260635-77-5
应用范围：
种属来源：
相关信息：
coumarin-SAHA Cayman Chemical Item Number 10671 Description Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.1↗ c-SAHA is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. 2↗ The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.2↗ This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening. Synonyms coumarin-Suberoylanilide Hydroxamic Acid Formal Name N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide CAS Number 1260635-77-5 Molecular Formula C18H22N2O5 Formula Weight 346.4 Formulation A crystalline solid Purity 98% Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES O=C(CCCCCCC(NO)=O)NC1=CC2=C(C(C)=CC(O2)=O)C=C1 InCHI Code 1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22) InCHI Key YSRCADVJNRJJAV-UHFFFAOYSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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