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Diallyl Trisulfide
Cayman Chemical Item Number 10012577
Description
Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor.1↗ It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM)2↗ and inhibits the growth of human colon adenocarcinoma HCT-15 cells (IC50 = 11.5 μM).3↗ DATS suppresses the growth of PC-3 xenografts in vivo in mice4↗ and induces vascular smooth muscle relaxation.1↗ Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.5↗,6↗
Synonyms NSC 651936,DATS
Formal Name di-2-propen-1-yl trisulfide
CAS Number 2050-87-5
Molecular Formula C6H10S3
Formula Weight 178.3
Formulation A solution in acetone
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C=CCSSSCC=C
InCHI Code 1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InCHI Key UBAXRAHSPKWNCX-UHFFFAOYSA-N |