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Diethylstilbestrol
Cayman Chemical Item Number 10006876
Description
Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring.1↗ DES is structurally related to, and is as potent as, estradiol in most assays, with a longer half-life. It has a relative binding affinity to sex hormone binding globulin (SHBG) of 0.2 compared to estradiol which has a relative binding affinity of 100. A concentration of 20 µM DES, displaces 30 ± 13% of 3H-estradiol from SHBG in serum.1↗,2↗
Formal Name 4,4'[(1E)-1,2-diethyl-1,2-ethenediyl]bis-phenol
CAS Number 56-53-1
Molecular Formula C18H20O2
Formula Weight 268.4
Formulation A crystalline solid
Purity ≥98%
λmax 240 nm
Stability 2 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CC\C(=C(\CC)/c1ccc(O)cc1)\c1ccc(O)cc1
InCHI Code 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
InCHI Key RGLYKWWBQGJZGM-ISLYRVAYSA-N |