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Dimebolin (hydrochloride)
Cayman Chemical Item Number 10011349
Description
Dimebolin (hydrochloride), also known as Dimebon™, is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s disease and Huntington’s disease. 1↗,2↗,3↗ In addition to preventing the onset and progression of disease by being neuroprotective, Dimebolin appears to promote clinical improvement by increasing cognitive function.4↗,2↗ At the cellular level, Dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels, inhibiting NMDA-type glutamate receptors, and preventing mitochondrial leakage.5↗,6↗,7↗ The hydrochloride form of Dimebolin is soluble in both aqueous and organic solvents.
Formal Name 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole, dihydrochloride
CAS Number 97657-92-6
Molecular Formula C21H25N3 · 2HCl
Formula Weight 392.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CN1CCc2n(CCc3ccc(C)nc3)c3ccc(C)cc3c2C1
InCHI Code 1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
InCHI Key JNODQFNWMXFMEV-UHFFFAOYSA-N |