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R848
R848 is an imidazoquinoline compound with potent anti-viral activity. This low molecular weight synthetic molecule activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway [1, 2].
Recently, R848 was shown to trigger NF-κB activation in cells expressing murine TLR8 when combined with poly(dT) [3].
Unlike other commercially available R848 preparations, InvivoGen's R848 is water soluble and controlled for TLR7/8 potency and TLR4/TLR2 contamination.
R848 is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: TLR7 and TLR8
Working Concentration: 10 ng - 10 μg/ml
Solubility:1 mg/ml in water
Formula: C17H22N4O2, HCl
Molecular weight: 350.8
CAS number: 144875-48-9 |