Poly(dT)

Poly(dT)
Poly(dT), a thymidine homopolymer phosphorothioate ODN, is a modulator of human TLR7 and TLR8. In combination with an imidazoquinoline, such as R848 and CL075, it increases TLR8-mediated signaling but abolishes TLR7-mediated signaling [1, 2]. Alone poly(dT) has no significant effect on either of these TLRs. Furthermore, co-incubation of poly(dT) and an imidazoquinoline was shown to induce NF-κB activation in HEK293 cells transfected with murine TLR8- and primary TLR8-expressing mouse cells, demonstrating that murine TLR8 is functional [3].
Specificity: TLR7/8 modulator
Working Concentration: 10 μM
Endotoxin level:  EndoFit™ (<0.001 EU/µg)
Solubility: 100 nmol/ml in water