ORN06/LyoVec™ ORN 06 contains 6 repeats of the UUGU sequence motif, identified as the minimal motif responsible for ssRNA40 immunoactivity. ORN06 is complexed with the cationic lipid LyoVec™, to protect it from degradation and facilitate it uptake. ORN 06/LyoVec™ has been tested using HEK-Blue™ TLR7 and HEK-Blue™ TLR8 Cells to confirm its specificity. Specificity: human TLR8/mouse TLR7 agonist Working Concentration: 0.25 - 5 μg/ml Sequence: ORN 06 5’-UUGUUGUUGUUGUUGUUGUU-3’ (20 mer) Endotoxin level: EndoFit™ (<0.001 EU/µg) Solubility: 0.05 mg/ml in water
