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MDP
Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1, 2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs [2]. The potent adjuvant activity of MDP may be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3].
MDP is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: NOD2 agonist
Working concentration: 10 ng - 10 µg/ml
Endotoxin level: <0.125 EU/mg
Solubility: 10 mg/ml in water
Formula: C19H32N4O11
Molecular weight: 492.5
Synonym: N-Acetylmuramyl-L-Alanyl-D-Isoglutamine (L-D isoform) |