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ssRNA41/LyoVec™
Negative control for ssRNA40/LyoVec
ssRNA41 is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine [1]. ssRNA4 [1] is complexed with the cationic lipid LyoVec™, to protect it from degradation and facilitate its uptake, and lyophilized to generate ssRNA41/LyoVec. Unlike ssRNA40, ssRNA41 is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 [1, 2].
Specificity: human TLR8/mouse TLR7 agonist
Working Concentration: 0.25 - 5 μg/ml
Sequence: ssRNA41 5’-GsCsCsCsGsAsCsAsGsAsAsGsAsGsAsGsAsCsAsC-3’
(“s” depicts a phosphothioate linkage)
Endotoxin level: EndoFit™ (<0.001 EU/µg)
Solubility: 0.05 mg/ml in water |