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H-89
PKA inhibitor
H-89 is a selective, potent cell permeable inhibitor of cAMP-dependent protein kinase (PKA). PKA is involved in the TLR-mediated TREM-1 expression on macrophages following LPS stimulation [1,2]. PKA inhibition with H-89 can also reduce IL-6 expression by 50% [3].
Working concentration: 5 - 50 µM
Purity: >99% (HPLC)
CAS number: 127243-85-0
Synonym: 5-isoquinolinesulfonamide, 2HCl
Formula: C20H20BrN3O2S 2HCl
Molecular weight: 519.3
Solubility: 50mg/ml in DMSO and ethanol, 25 mg/ml in H2O (heat to dissolve)
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