|
Glybenclamide
NLRP3 Inflammasome Inhibitor - Proton pump inhibitor
Glybenclamide, also known as glyburide, blocks the maturation of caspase-1 and pro-IL-1β by inhibiting the K+ efflux [1]. Glybenclamide was shown to potently block the activation of the NRLP3 inflammasome induced by PAMPs, DAMPs and crystalline substances [2, 3]. Recent data suggest that glybenclamide works downstream of the P2X7 receptor but upstream of NRLP3 [2].
Working concentration: 25 μg/ml
CAS Number: 10238-21-8
Purity: 98%
Molecular weight: 494
Solubility: Soluble in DMSO (25 mg/ml) and ethanol (5 mg/ml) |