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CLI-095
TLR4 signaling inhibitor
CLI-095, also known as TAK-242, is a novel cyclohexene derivative that suppresses specifically TLR4 signaling, inhibiting the production of NO and pro-inflammatory cytokines [1]. It acts by blocking the signaling mediated by the intracellular domain of TLR4, but not the extracellular domain. It potently suppresses both ligand-dependent and -independent signaling of TLR4 [2].
Working concentration: 50 nM- 5 μM
Endotoxin level: <0.125 EU/mg
Solubility: DMSO (1 mg/ml)
Molecular weight: 361.82 |